Fosfomycin resistance in Escherichia coli in Japan.

نویسندگان

  • M Shimizu
  • T Nonomiya
  • F Shigenobu
  • K O'Hara
  • T Sawai
چکیده

Fosfomycin, [L-(cis)-1, 2-epoxypropyl phosphonic acid] (FOM), a broad spectrum antibiotic produced by some strains of Streptomyces species1), acts as a phosphoenolpyruvate analog and irreversibly inhibits phosphoenolpyruvate UDP-N-acetylglucosamine (UDPG1cNAc)-3-O-enolpyruvyl transferase, an enzyme which catalyzes the first step of peptidoglycan biosynthesis2). FOM enters susceptible bacteria by means of two dif-

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 51 9  شماره 

صفحات  -

تاریخ انتشار 1998